Miljöpåverkan
Piroxikam
Miljörisk:
Risk för miljöpåverkan av piroxikam kan inte uteslutas då ekotoxikologiska data saknas.
Nedbrytning:
Det kan inte uteslutas att piroxikam är persistent, då data saknas.
Bioackumulering:
Piroxikam har låg potential att bioackumuleras.
Läs mer
Detaljerad miljöinformation
Environmental Risk Classification
Predicted Environmental Concentration (PEC)
PEC is calculated according to the following formula:
PEC (μg/L) = (A*109*(100-R))/(365*P*V*D*100) = 1,37*10-6*A(100-R)
PEC = 1,34 x 10-3 μg/L
Where:
A = 9,8047 kg (total sold amount API in Sweden year 2021, data from IQVIA).
R = 0% removal rate (due to loss by adsorption to sludge particles, by volatilization, hydrolysis or biodegradation) = 0 if no data is available.
P = number of inhabitants in Sweden = 10*106
V (L/day) = volume of wastewater per capita and day = 200 (ECHA default) (Ref.1)
D = factor for dilution of waste water by surface water flow = 10 (ECHA default) (Ref.1)
Predicted No Effect Concentration (PNEC)
Data not available
Environmental risk classification (PEC/PNEC ratio)
Risk of environmental impact of piroxicam cannot be excluded, since there is not sufficient ecotoxicity data available.
Degradation
Data not available
Bioaccumulation
Partitioning coefficient:
Log Pow = 3,06 (experimentally derived, unknown method) (Ref. 2)
Since log Pow < 4, the substance has low potential for bioaccumulation.
References
1. ECHA, European Chemicals Agency. 2008 Guidance on information requirements and chemical safety assessment. http://guidance.echa.europa.eu/docs/guidance_document/information_requirements_en.htm
2. Avdeef A et al (1997), United States National Library of Medicine, PubChem, Compound, Piroxicam, http://pubchem.ncbi.nlm.nih.gov/. Accesses: 14 July 2015